Category Archives: english

High on life

I’ve discovered the joy of roller skating in San Francisco. Truly amazing:)

You can get all the drugs, the alcohol, anything you want to get you high,  but no matter what, it’s gonna run its course, you’re gonna come down. When you get high on life, out there with dancing, you can go higher than you can even imagine, cause you can stay as long as you want to stay there. And when you do want to come down, there’s no side effects, and you didn’t pay a thing, it’s totally free.

It was a sunny day, I slowed down a little bit :

Crisper

The other day, I had the chance to stumble on Jennifer Doudna in Stanley Hall… And I asked her for a drawing !

Jennifer Doudna's drawing

Jennifer Doudna’s drawing

Jennifer Doudna is well-known for her discovery, with her postdoc Martin Jinek and Emmauelle Charpentier, of the CRISPR-Cas9 technology, that allows live gene editing.

It might not seem that crazy, but it’s a total game changer (Radiolab had a good story about it recently). The thing is that until now, to modify the genes, one had to change the germ cell and create a new living being : an already existing being could not have its DNA reprogrammed. But now, you can cure genetic diseases and target specific genes that you would like to change (I don’t know if you can change the colors of your eyes by that process, but who really cares ?)

This of course brings a lot of ethical questions that they try to tackle— I can’t help but to  imagine how terrible a biological weapon targeting a population through specific would be.

For her work, DouDNA and Charpentier were awarded the Breakthrough Prize in Life Science, a prestigious prize put together by Yuri Milner and others. She will probably be promoted to my Nobel Prize list soon:)

edit November 10th :

No Nobel Prize this year, but another Breakthrough prize, from optogenetics !
Watch the related Breakthrough Symposium talks
And another piece in the New Yor Times : the CRISPR quandary.

Fun to imagine

I’ve received this very kind email, related to a transcript I’ve made a while back :

Dear Antoine Wojdyla,

By chance I have just come across your excellent English transcript of the Richard Feynman ‘Fun to Imagine’ episodes and I thought how wonderful it is that you have gone to the trouble of doing this. I produced the programmes back in 1983 and it’s great that they are still out there and people seem to enjoy them.
Anyway, I thought I’d write and say thank you!

Best wishes,

Christopher Sykes

nice_treeHere’s an excerpt from the transcript “fun to imagine“:

The sun is shining, and this sunlight comes down and knocks this oxygen away from the carbon, so it takes some light to get the plant to work! And so the sun, all the time, is doing the work of separating the oxygen away from the carbon, the oxygen is sort a of terrible by-product, which it spits back into the air, an leave in the carbon and water to make the substance of the tree. And then we take the substance of the tree to get the fireplace. All the oxygen made by these trees and all the carbons would much prefer to be together again. And once you let the heat to get it started, it continues and make an awful lot of activity while it’s going back together again, and all those nice light and everything comes out, and everything is being undone, you’re going from carbon and oxygen back to carbon dioxide, and the light and heat that’s coming out is the light and heat of the sun that went in, so it’s sort of stored sun that is coming out when you burn it.

Information in optics

Dear reader,

I’ve compiled here, just for you, three old article that I’ve OCRed and revamped a little bit. They are article with a lot of style and insight, that people sometimes cite without ever reading them… mostly because they’re not readily available. That’s the silly situation I wanted to fix.
– Enjoy !

Zernike – Physica IX, no 7 (1942)
Phase Contrast, A New Method for the Microscopic Observation of Transparent Object

Gerchberg and Saxton – Optik Vol. 35, No.2 (1972)
A Practical Algorithm for the Determination of Phase from Image and Diffraction Plane Pictures

Gabor – Progress in Optics Vol. 1 (1951)
Light and information” (still under revision)

Here’s a blissful excerpt from Gabor’s piece :

Light is our most powerful source of information on the physical world. Anthropologists have often emphasized that the privileged position of Man is due as much to his exceptionally perfect eye, as to his large brain. I was much impressed by a remark of Aldous Huxley, that we owe our civilization largely to the fact that vision is an objective sense. An animal with an olfactory sense or with hearing, however well developed, could never have created science. A smell is either good or bad, and even hearing is never entirely neutral; music can convey emotions with an immediateness of which the sober visual arts are incapable. No wonder that the very word “objective” has been appropriated by optics. But on the other hand it is probably the peculiar character of vision which is chiefly responsible for one of the most deep-rooted of scientific prejudices; that the world can be divided into an outer world and into an “objective” observer, who observes “what there is”, without influencing the phenomena in the slightest.

Tukey – Annals of Statistical Mathematics
The future of data analysis” (1961) — still working on it

Zernike – Physica I, pp. 689-704 (1932)
Diffraction theory of the knife-edge test and its improved form“,
translation by Anthony Yen (who went all in by redrawing all the figures !)

gabor_perpetual

A gedankenexperiment by Gabor, to discuss the nature of information contained in light

 

— Thanks to Martin Burkhardt for sharing some of these pieces !

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Modern Poetry

I like to encounter poetry, where you don’t expect it.
Here is some, in loose leaves.

The (East Bay Express) news in Haiku

Bristlr: The Tinder for Beards
Beard lovers and beard-
havers, rejoice! This app is
here to shave the day.

Mark Kozelek’s Perils from the sea :

(I’ll keep updating this post!)

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Marguerite Duras, 1985

Alexis Madrigal just published my translation of Marguerite Duras (Fusion.net)

Fusion

Here’s an excerpt :

In the 2000s, there will be only answers. The demand will be such that there will only be answers. All texts will be answers, in fact. I believe that man will be literally drowned in information, in constant information. About his body, his corporeal future, his health, his family life, his salary, his leisure.

Alexis Madrigal is the Silicon Valley Chief at Fusion, and a former senior editor at The Atlantic.
He is my favorite writer about the implication of technology on our daily life, alongside with Evgueny Morozov and Sean Gourley, even the the latters tend to be too dark and serious sometimes.

He is editing a great newsletter : 5 Intriguing Things, my daily dose of sci-fi.
edit Feb 10th, 2015 : now the newsletter’s name has turned into Real Future.

Shiftings : from electronics to photonics ?

Photons and electrons like to play together in atoms, but much less so in computers…

Like EUV lithography, people have been talking about optical computers for a long time, and that still hasn’t materialized.
Like EUV, it seems that we’re on the verge of a major shift !

north-laserLet’s review some of the differences between electronics and optics !

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Seeing small

I don’t know how to do this on a small scale in a practical way, but I do know that computing machines are very large; they fill rooms. Why can’t we make them very small, make them of little wires, little elements – and by little, I mean little. For instance, the wires should be 10 or 100 atoms in diameter, and the circuits should be a few thousand angstroms across.
– Richard Feynman (1959)

Being  a researcher, all my friends and family have very little idea of what I’m work on. The trouble is that when I try to explain, I need to resort to notions such as wavelength or transistor, only to discover that most people have no clue of what this is, expect to joke about being on the same… wavelength. But very small wavelength.

To put it straight : I look at small things.

Yet, I was just awarded a prize for best research at the EUV lithography symposium in Washington, D.C., and it’s only fair of me to explain what I’m doing for a living!

sharp_photo

The SHARP EUV microscope I’m working with

 

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Beautiful SEM pictures

I had the chance to help my friend Sylvie to get scanning electron microscope pictures of the MRI contrast agent she synthesizes, and we collected gorgeous data thanks to my colleague Farhad.
He told me that he had TONS of failed experiments that still yielded great pictures…
We should start a journal of the failed experiments… art+science mag !:)

Islands...

SEM picture that looks like an aerial view of Dog Island (Anguilla)…

I guess there is some wabi-sabi in science…

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Love and Confidence in science

Recent events in the scienfic community – I’m thinking of the detection of primordial B-mode signal in the CMB polarization by BICEP2 (probable), the discovery of Higgs Boson (Nobel-prized) and of the faster-than-light neutrinos (ruled out as an experimental error) – invite us to draw a line between what is reasonable science and what is not.

Saul Perlmutter talking about exotic theories in astrophysics

Saul Perlmutter talking about exotic theories in astrophysics

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